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Furosemide has been associated with negative fluid balance, shorter duration of mechanical ventilation, and a stronger effect in patients with LV systolic dysfunction. 27,29 Nitrates cause systemic venous dilatation leading to a reduction of central blood volume, arterial vasodilatation and thus a reduction in LV afterload, and coronary .
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LV remodeling occurs spontaneously among patients with HCM in several ways: (1) wall thickening, otherwise defined as positive remodeling; (2) wall thinning without impairment of LV systolic function, defined as benign remodeling; (3) a gradual wall thinning process resulting in the loss of LV systolic function or the development of LV .
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