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Both feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) are retroviruses. Unlike some forms of virus that infect cells and then kill them, retroviruses actually alter the genetic material of the .
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In this study, we investigated the in vivo generation of CD4 + CAR T cells using CD4-targeted LV (CD4-LV). Administration of CD4-LV into NSG mice transplanted with human peripheral blood mononuclear cells (PBMCs) led to 40%-60% of human CD4 + lymphocytes being CAR positive while CD8 + cells remained CAR negative.
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